Linked Life Data

16902595

Source:http://linkedlifedata.com/resource/pubmed/id/16902595

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2006-8-11
pubmed:abstractText
Small ions and molecules can traverse the nuclear pore complex (NPC) simply by diffusion, whereas larger proteins and RNAs require specific signals and factors that facilitate their passage through the NPC. Our understanding of the factors that participate and regulate nucleocytoplasmic transport has increased tremendously over the past years, whereas the actual translocation step through the NPC has remained largely unclear. Here, we present and discuss recent findings on the interaction between the NPC and transport receptors and provide new evidence that the NPC acts as a constrained diffusion pore for molecules and particles without retention signal and as an affinity gate for signal-bearing cargos.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0008-4212
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
499-507
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Getting across the nuclear pore complex: new insights into nucleocytoplasmic transport.
pubmed:affiliation
ME Müller Institute, Biozentrum, University of Basel, Switzerland. Daniel.Stoffler@unibas.ch
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't