Source:http://linkedlifedata.com/resource/pubmed/id/16897004
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2006-8-25
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| pubmed:abstractText |
The aim of the study was to analyze systematically our observation that children with severe nephrotic syndrome (NS) have hyperphosphatemia despite normal kidney function. Forty-seven children with NS and normal glomerular filtration rate (GFR) were studied [26 with steroid-sensitive nephrotic syndrome (SSNS) and 21 with persistent NS]. The plasma phosphate level was expressed as the number of standard deviations (SDs) from the mean levels in age- and gender-matched controls. In SSNS plasma phosphate concentration was elevated (+3.7+/-2.0 SDs) during relapse and normalized (-0.7+/-1.7 SDs) in remission. In persistent NS the phosphate level was +4.0+/-2.1 SDs. Patients with marked hyperphosphatemia (>4 SDs) were younger (p<0.001), had lower plasma albumin (p<0.001), and had higher urinary protein levels (p<0.05). Hyperphosphatemia did not correlate with GFR, plasma calcium, or urinary sodium levels. Children with persistent NS had decreased serum 25(OH)D(3) and insulin-like growth factor 1 (IGF-1) concentrations. Hyperphosphatemia is prevalent among children with persistent nephrotic syndrome and normal renal function, correlates with its severity, and may result from increased urinary IGF-1 wasting.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0931-041X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1406-12
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| pubmed:meshHeading |
pubmed-meshheading:16897004-Adolescent,
pubmed-meshheading:16897004-Calcium,
pubmed-meshheading:16897004-Child,
pubmed-meshheading:16897004-Child, Preschool,
pubmed-meshheading:16897004-Creatinine,
pubmed-meshheading:16897004-Female,
pubmed-meshheading:16897004-Glomerular Filtration Rate,
pubmed-meshheading:16897004-Humans,
pubmed-meshheading:16897004-Infant,
pubmed-meshheading:16897004-Insulin-Like Growth Factor I,
pubmed-meshheading:16897004-Kidney,
pubmed-meshheading:16897004-Male,
pubmed-meshheading:16897004-Metabolic Diseases,
pubmed-meshheading:16897004-Nephrotic Syndrome,
pubmed-meshheading:16897004-Phosphates,
pubmed-meshheading:16897004-Prevalence,
pubmed-meshheading:16897004-Retrospective Studies,
pubmed-meshheading:16897004-Severity of Illness Index,
pubmed-meshheading:16897004-Sodium
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Hyperphosphatemia is prevalent among children with nephrotic syndrome and normal renal function.
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| pubmed:affiliation |
Division of Pediatric Nephrology, Shaare Zedek Medical Center, P.O. Box 3235, Jerusalem 91031, Israel.
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| pubmed:publicationType |
Journal Article
|