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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-8-7
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pubmed:abstractText |
ATL-146e protects the spinal cord from ischemia/reperfusion injury, presumably via adenosine A(2A) receptor activation, but this relationship remains unproven. We hypothesized that spinal cord functional and cytoarchitectural preservation from ATL-146e would be lost with simultaneous administration of the specific adenosine A(2A) antagonist ZM241385 (ZM), thus proving that adenosine A(2A) receptor activation is responsible for the protective effects of this compound.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATL 146e,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine A2 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine A2 Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanecarboxylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Adenosine A2A,
http://linkedlifedata.com/resource/pubmed/chemical/Triazines,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/ZM 241385
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0741-5214
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
392-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16890874-Adenosine A2 Receptor Agonists,
pubmed-meshheading:16890874-Adenosine A2 Receptor Antagonists,
pubmed-meshheading:16890874-Animals,
pubmed-meshheading:16890874-Cell Survival,
pubmed-meshheading:16890874-Cyclohexanecarboxylic Acids,
pubmed-meshheading:16890874-Disease Models, Animal,
pubmed-meshheading:16890874-Microtubule-Associated Proteins,
pubmed-meshheading:16890874-Neurons,
pubmed-meshheading:16890874-Neuroprotective Agents,
pubmed-meshheading:16890874-Paraplegia,
pubmed-meshheading:16890874-Purines,
pubmed-meshheading:16890874-Rabbits,
pubmed-meshheading:16890874-Receptor, Adenosine A2A,
pubmed-meshheading:16890874-Reperfusion Injury,
pubmed-meshheading:16890874-Spinal Cord,
pubmed-meshheading:16890874-Spinal Cord Ischemia,
pubmed-meshheading:16890874-Time Factors,
pubmed-meshheading:16890874-Triazines,
pubmed-meshheading:16890874-Triazoles
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pubmed:year |
2006
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pubmed:articleTitle |
Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism.
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pubmed:affiliation |
Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA. tbr5q@virginia.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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