Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-10-27
pubmed:abstractText
Genetic analysis of transcriptional regulation is a rapidly emerging field of investigation that promises to shed light on the regulatory networks that control gene expression. Although a number of such studies have been carried out, the nature and extent of the heritability of gene expression traits have not been well established. We describe the inheritance of transcript levels in liver tissue in the first filial (F1) generation of mice obtained from reciprocal crosses between the common inbred strains A/J and C57BL/6J. We obtain estimates of genetic and technical variance components from these data and demonstrate that shrinkage estimators can increase detectable heritability. Estimates of heritability vary widely from transcript to transcript, with one-third of transcripts showing essentially no heritability (<0.01) and one-quarter showing very high heritability (>0.50). Roughly half of all transcripts are differentially expressed between the two parental strains. Most transcripts show an additive pattern of inheritance. Dominance effects were observed for 20% of transcripts and a small number of transcripts were identified as showing an overdominance mode of inheritance. In addition, we identified 314 transcripts with expression levels that differ between the reciprocal F1 animals. These genes may be related to maternal effect.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-10615122, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-11232561, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-11470909, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-11923494, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-11951044, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-12454643, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-12582260, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-12646905, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-12646919, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-14519205, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-14523245, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-14722723, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-14764857, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-14960456, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15269782, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15342517, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15452887, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15489529, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15514893, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15618528, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15711544, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15711545, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15711547, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15919809, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-15944359, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-16020790, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-16143608, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-16154229, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-16172500, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-16188930, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-6770678, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-9539413, http://linkedlifedata.com/resource/pubmed/commentcorrection/16888332-9915498
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
174
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
627-37
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Inheritance patterns of transcript levels in F1 hybrid mice.
pubmed:affiliation
Department of Biostatistics, Section on Statistical Genetics, Department of Medicine, Genetic and Translational Medicine Division, University of Alabama, Alabama 35294, USA. xcui@uab.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural