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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-9-15
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pubmed:abstractText |
Perinatal hypoxia-ischemia is one of the most common risk factors for neonatal mortality and permanent neurodevelopmental disability. Topiramate [2,3:4,5-bis-o-(1-methylethylidene) beta-D-fructo-pyranose sulfamate; TPM] is widely used as an antiepileptic agent with multiple targets. In the present study, we found that treatment with TPM reduced the neuronal damage induced by oxygen-glucose deprivation in vitro with strong inhibition of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor. Because perinatal hypoxia is mediated, at least in part, by aberrant glutamatergic excitation, we tested whether treatment with TPM was effective against perinatal brain hypoxia-ischemia. Intraperitoneal or oral pretreatment with TPM was found to reduce the brain damage and subsequent cognitive impairments induced by transient hypoxia-ischemia in perinatal rats. A potent neuroprotective effect of TPM was also observed in a post-treatment regime although post-treatment window appears to be relatively narrow (<2 h). These results suggest that TPM treatment may be beneficial for perinatal hypoxia-ischemia and related damage.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Fructose,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Amino-3-hydroxy-5-methyl-4-iso...,
http://linkedlifedata.com/resource/pubmed/chemical/topiramate
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-4886
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
470-8
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pubmed:dateRevised |
2007-2-23
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pubmed:meshHeading |
pubmed-meshheading:16884714-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:16884714-Administration, Oral,
pubmed-meshheading:16884714-Animals,
pubmed-meshheading:16884714-Animals, Newborn,
pubmed-meshheading:16884714-Behavior, Animal,
pubmed-meshheading:16884714-Cell Hypoxia,
pubmed-meshheading:16884714-Cell Survival,
pubmed-meshheading:16884714-Cells, Cultured,
pubmed-meshheading:16884714-Dose-Response Relationship, Drug,
pubmed-meshheading:16884714-Excitatory Amino Acid Agonists,
pubmed-meshheading:16884714-Excitatory Amino Acid Antagonists,
pubmed-meshheading:16884714-Fructose,
pubmed-meshheading:16884714-Hypoxia-Ischemia, Brain,
pubmed-meshheading:16884714-Injections, Intraperitoneal,
pubmed-meshheading:16884714-Maze Learning,
pubmed-meshheading:16884714-N-Methylaspartate,
pubmed-meshheading:16884714-Neurons,
pubmed-meshheading:16884714-Neuroprotective Agents,
pubmed-meshheading:16884714-Rats,
pubmed-meshheading:16884714-Rats, Sprague-Dawley,
pubmed-meshheading:16884714-Receptors, AMPA,
pubmed-meshheading:16884714-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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pubmed:year |
2006
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pubmed:articleTitle |
Neuroprotective effect of topiramate on hypoxic ischemic brain injury in neonatal rats.
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pubmed:affiliation |
Department of Anatomy and Division of Brain Korea 21 Biomedical Science, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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