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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001128,
umls-concept:C0072899,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0243072,
umls-concept:C0268563,
umls-concept:C0456387,
umls-concept:C0679622,
umls-concept:C1707689,
umls-concept:C1709060,
umls-concept:C1883254
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|
pubmed:issue |
19
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|
pubmed:dateCreated |
2006-8-25
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|
pubmed:abstractText |
The synthesis and initial SAR studies of novel, highly potent positive allosteric modulators of AMPA receptors based on 3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid (6a) are described. SAR studies at the thioether moiety indicated that substitution at this position was mandatory and better potency was achieved with small groups.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:CastañoAnaA,
pubmed-author:DominguezEstebanE,
pubmed-author:EscribanoAnaA,
pubmed-author:FernandezMaria-CarmenMC,
pubmed-author:HongEricE,
pubmed-author:HornbackWilliam JWJ,
pubmed-author:JiangDeluD,
pubmed-author:JimenezAlmaA,
pubmed-author:NisenbaumEric SES,
pubmed-author:RanklNancyN,
pubmed-author:TromiczakEricE,
pubmed-author:VaughtGrantG,
pubmed-author:ZarrinmayehHamidehH,
pubmed-author:ZimmermanDennis MDM
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5057-61
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives.
|
|
pubmed:affiliation |
Lilly S.A., Avenida de la Industria, 30, 28108 Alcobendas, Madrid, Spain. fernandez_maria-carmen@lilly.com
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|
pubmed:publicationType |
Journal Article
|
