Linked Life Data

16877118

Source:http://linkedlifedata.com/resource/pubmed/id/16877118

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-7-31
pubmed:abstractText
Neurologic diseases often are accompanied by significant life stress and consequent increases in stress hormone levels. Glucocorticoid stress hormones are known to have deleterious interactions with neurodegenerative processes and are hypersecreted in neurologic disorders and comorbid psychiatric conditions. This review highlights the current state of knowledge of mechanisms controlling activation and inhibition of glucocorticoid secretion, outlines signalling mechanisms used by these hormones in neural tissue, and describes how endogenous glucocorticoids can mitigate neuronal damage in models of neurologic disease. This review highlights the importance of controlling stress and consequent stress hormone secretion in the context of neurologic disease states.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0733-8619
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
461-81, vi
pubmed:dateRevised
2009-4-24
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Hypothalamic-pituitary-adrenal axis, glucocorticoids, and neurologic disease.
pubmed:affiliation
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45237-0506, USA. james.herman@uc.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural