Linked Life Data

16868551

Source:http://linkedlifedata.com/resource/pubmed/id/16868551

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2006-7-26
pubmed:abstractText
Accurate cellular localization is crucial for the effective function of most signalling molecules and nuclear translocation is central to the function of transcription factors. The passage of large molecules between the cytoplasm and nucleus is restricted, and this restriction affords a mechanism to regulate transcription by controlling the access of transcription factors to the nucleus. In this Review, we focus on the signal transducer and activator of transcription (STAT) family of transcription factors. The regulation of the nuclear trafficking of STAT-family members is diverse. Some STAT proteins constitutively shuttle between the nucleus and cytoplasm, whereas others require tyrosine phosphorylation for nuclear localization. In either case, the regulation of nuclear trafficking can provide a target for therapeutic intervention.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1474-1733
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
602-12
pubmed:dateRevised
2007-7-25
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Tracking STAT nuclear traffic.
pubmed:affiliation
Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11777, USA. nancy.reich@stonybrook.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural