Source:http://linkedlifedata.com/resource/pubmed/id/16867604
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2006-7-26
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| pubmed:abstractText |
An automated liquid chromatographic method for the determination of omeprazole and two metabolites in plasma and urine is described. It utilizes the Technicon Fully-Automated-Sample-Treatment-LC system (FAST(R)-LC). Sample preparation is achieved by air-segmented continuous-flow providing solvent extraction, evaporation to dryness and reconstitution before injection onto a reversed-phase column. The compounds are separated by isocratic or gradient elution with acetonitrile-phosphate buffer mobile phases and quantified by UV-measurements at 302 nm. The limit of determination (relative standard deviation 10-15%) is 50 nmol l(-1) in plasma (800 microl) and 200 nmol l(-1) in urine (200 microl). The sample capacity is six or three samples per hour, depending on the elution mode.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:issn |
0731-7085
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
389-98
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| pubmed:year |
1986
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| pubmed:articleTitle |
Fully automated gradient elution liquid chromatographic assay of omeprazole and two metabolites.
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| pubmed:affiliation |
Bioanalytical Chemistry, AB Hässle, S-431 83 Mölndal, Sweden.
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| pubmed:publicationType |
Journal Article
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