Source:http://linkedlifedata.com/resource/pubmed/id/16860028
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2006-7-24
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| pubmed:abstractText |
A randomized, double-blind study of 6 months of losartan 50 mg or hydrochlorothiazide (HCTZ) 12.5 mg was performed in 40 subjects with left ventricular diastolic dysfunction (mitral flow velocity E/A ratio < 1), exercise systolic blood pressure (BP) > 200 mm Hg, systolic BP at rest < 150 mm Hg, ejection fraction > 50%, and no ischemia. Before treatment, exercise systolic BP was 213 +/- 13 mm Hg (mean +/- SD) in the 19 patients randomized to losartan and 209 +/- 11 mm Hg in the 21 patients who received HCTZ. After 6 months, exercise systolic BP was similarly reduced in patients who received losartan (197 +/- 23 mm Hg, p < 0.01) and HCTZ (191 +/- 11 mm Hg, p < 0.01). With losartan, treadmill exercise time increased from 894 +/- 216 to 951 +/- 225 seconds (p = 0.011), and quality of life improved from 15 +/- 12 to 7 +/- 10 (p = 0.015) without a change in oxygen consumption (1,895 +/- 470 to 1,954 +/- 539 ml/min, p = 0.30). With HCTZ, exercise time (842 +/- 225 to 872 +/- 239 seconds, p = 0.32) and quality of life (19 +/- 21 vs 19 +/- 24, p = 0.43) did not change, whereas oxygen consumption decreased from 2,144 +/- 788 to 1,960 +/- 706 ml/min (p = 0.022). In conclusion, in patients with diastolic dysfunction and hypertensive responses to exercise, 6 months of losartan and HCTZ blunted systolic BP during exercise. Only losartan increased exercise tolerance and improved quality of life.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0002-9149
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
98
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
383-5
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16860028-Antihypertensive Agents,
pubmed-meshheading:16860028-Blood Pressure,
pubmed-meshheading:16860028-Diastole,
pubmed-meshheading:16860028-Diuretics,
pubmed-meshheading:16860028-Double-Blind Method,
pubmed-meshheading:16860028-Echocardiography, Doppler,
pubmed-meshheading:16860028-Exercise Tolerance,
pubmed-meshheading:16860028-Female,
pubmed-meshheading:16860028-Follow-Up Studies,
pubmed-meshheading:16860028-Heart Ventricles,
pubmed-meshheading:16860028-Humans,
pubmed-meshheading:16860028-Hydrochlorothiazide,
pubmed-meshheading:16860028-Hypertension,
pubmed-meshheading:16860028-Losartan,
pubmed-meshheading:16860028-Male,
pubmed-meshheading:16860028-Middle Aged,
pubmed-meshheading:16860028-Myocardial Contraction,
pubmed-meshheading:16860028-Physical Exertion,
pubmed-meshheading:16860028-Treatment Outcome,
pubmed-meshheading:16860028-Ventricular Dysfunction, Left
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| pubmed:year |
2006
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| pubmed:articleTitle |
Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction.
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| pubmed:affiliation |
Cardiology Section, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. wlittle@wfubmc.edu
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|