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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-1-16
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pubmed:abstractText |
Loss of the cyclin-dependent kinase inhibitor p27 is associated with poor prognosis in breast cancer. The decrease in p27 levels is mainly the result of enhanced proteasome-dependent degradation mediated by its specific ubiquitin ligase subunit S phase kinase protein 2 (Skp2). The mammalian target of rapamycin (mTOR) is a downstream mediator in the phosphoinositol 3' kinase (PI3K)/Akt pathway that down-regulates p27 levels in breast cancer. Rapamycin was found to stabilize p27 levels in breast cancer, but whether this effect is mediated through changes in Skp2 expression is unknown.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-10073286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-10559916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-10559918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-10611969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-10693755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-11010972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-11309491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-11335900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-11426655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-11439332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-11522658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-11526226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-11606446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-11731414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-12208864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-12242656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-12244301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-12244302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-12429629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-12730199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-14871980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-15014502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-15014503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-15136596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-15668399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-15799239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-16168119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-2547513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-7553852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-7624798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16859513-8596954
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-542X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R46
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16859513-Breast Neoplasms,
pubmed-meshheading:16859513-Cell Line, Tumor,
pubmed-meshheading:16859513-Down-Regulation,
pubmed-meshheading:16859513-Enzyme Inhibitors,
pubmed-meshheading:16859513-Female,
pubmed-meshheading:16859513-Humans,
pubmed-meshheading:16859513-Ligases,
pubmed-meshheading:16859513-Protein Kinases,
pubmed-meshheading:16859513-S-Phase Kinase-Associated Proteins,
pubmed-meshheading:16859513-Sirolimus,
pubmed-meshheading:16859513-TOR Serine-Threonine Kinases,
pubmed-meshheading:16859513-Ubiquitin
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pubmed:year |
2006
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pubmed:articleTitle |
The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.
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pubmed:affiliation |
Department of Surgery A, Rambam Medical Center, Haifa 31096, Israel. m_shapira@rambam.health.gov.il
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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