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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-7-21
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pubmed:abstractText |
The ABCB1 3435C-->T single-nucleotide polymorphism (SNP) or a three-SNP haplotype containing 3435C-->T has been implicated in multidrug resistance in epilepsy in three retrospective case-control studies, but a further three have failed to replicate the association. We aimed to determine the effect of the ABCB1 gene on epilepsy drug response, using a unique large cohort of epilepsy patients with prospectively measured seizure and drug response outcomes.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1474-4422
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pubmed:author |
pubmed-author:AndrewTobyT,
pubmed-author:BaldingDavid JDJ,
pubmed-author:BentleyDavid RDR,
pubmed-author:ChadwickDavid WDW,
pubmed-author:CoffeyAlison JAJ,
pubmed-author:JohnsonMichael RMR,
pubmed-author:JorgensenAndrea LAL,
pubmed-author:LeschzinerGuyG,
pubmed-author:MarsonAnthony GAG,
pubmed-author:MiddleditchClaireC,
pubmed-author:PirmohamedMunirM,
pubmed-author:RogersJaneJ,
pubmed-author:WilliamsonPaula RPR
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
668-76
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pubmed:dateRevised |
2007-8-13
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pubmed:meshHeading |
pubmed-meshheading:16857572-ATP-Binding Cassette Transporters,
pubmed-meshheading:16857572-Adult,
pubmed-meshheading:16857572-Anticonvulsants,
pubmed-meshheading:16857572-Case-Control Studies,
pubmed-meshheading:16857572-Cohort Studies,
pubmed-meshheading:16857572-Drug Resistance, Multiple,
pubmed-meshheading:16857572-Epilepsy,
pubmed-meshheading:16857572-Female,
pubmed-meshheading:16857572-Humans,
pubmed-meshheading:16857572-Male,
pubmed-meshheading:16857572-Middle Aged,
pubmed-meshheading:16857572-Polymorphism, Single Nucleotide,
pubmed-meshheading:16857572-Predictive Value of Tests,
pubmed-meshheading:16857572-Time Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study.
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pubmed:affiliation |
Division of Neurosciences, Imperial College London, London, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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