Source:http://linkedlifedata.com/resource/pubmed/id/16857296
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2007-7-27
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| pubmed:abstractText |
High white matter grade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. Higher ventricular size is a marker of brain "atrophy." In the Cardiovascular Health Study (CHS) (n=3245) mean age 75 years, 50% black and 40% men, we evaluated WM and ventricular grade (VG), total, cardiovascular and noncardiovascular mortality and longevity before and after adjusting for numerous determinants of longevity over an approximate 10-12 years of follow-up. A low WMG and VG was a marker for low total, cardiovascular and noncardiovascular mortality and for increased longevity over 10+ years of follow-up. We estimated that a 75-year-old with WMG below median would have about a 5-6 years greater longevity and for VG about 3 years, than above the median even after adjustment for numerous risk factors. Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1558-1497
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1307-15
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| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:16857296-African Continental Ancestry Group,
pubmed-meshheading:16857296-Aged,
pubmed-meshheading:16857296-Aged, 80 and over,
pubmed-meshheading:16857296-Biological Markers,
pubmed-meshheading:16857296-Brain,
pubmed-meshheading:16857296-Cardiovascular Diseases,
pubmed-meshheading:16857296-Cerebral Ventricles,
pubmed-meshheading:16857296-European Continental Ancestry Group,
pubmed-meshheading:16857296-Female,
pubmed-meshheading:16857296-Geriatric Assessment,
pubmed-meshheading:16857296-Health Status,
pubmed-meshheading:16857296-Humans,
pubmed-meshheading:16857296-Longitudinal Studies,
pubmed-meshheading:16857296-Magnetic Resonance Imaging,
pubmed-meshheading:16857296-Male,
pubmed-meshheading:16857296-Retrospective Studies,
pubmed-meshheading:16857296-Risk Factors,
pubmed-meshheading:16857296-Sex Factors
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study.
|
| pubmed:affiliation |
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, 130 N. Bellefield Ave., Rm. 550, Pittsburgh, PA 15213, United States. kullerl@edc.pitt.edu <kullerl@edc.pitt.edu>
|
| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|