Source:http://linkedlifedata.com/resource/pubmed/id/16855624
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2006-9-21
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pubmed:abstractText |
Pulse pressure (PP) is emerging as a major pressure predictor of cardiac disease. The study comprised 10 185 untreated patients with essential hypertension. A total of 5395 men and 4790 women 56+/-13 years old, with uncomplicated essential hypertension, after a 15-day washout period and after 6 months of antihypertensive monotherapy were included. All patients included in the final cohort were responders and had normalized their blood pressure. PP was decreased least with diuretics (-5 mm Hg) and most with angiotensin II receptor blockers (ARBs) and calcium antagonists (-15 mm Hg), followed by angiotensin-converting enzyme inhibitors (ACEI) (-12 mm Hg) alpha- and beta-blockers (-10 and -9 mm Hg), differentiating among antihypertensive classes (P<0.001). The magnitude of PP fall was related to the degree of left ventricular (LV) mass reduction (P<0.001), seen best with ARBs (r=0.42) and least with ACEIs (r=0.18). Of the antihypertensive medications used in everyday practice, PP decrease may be achieved best with ARBs and calcium antagonists, whereas diuretics confer poor response. PP was decreased least with diuretics (-5 mm Hg) and most with ARBs and calcium channel blockers (-15 mm Hg), followed by ACEI (-12 mm Hg) alpha- and beta-blockers (-10 and -9 mm Hg), differentiating among antihypertensive classes (P<0.001). Of the antihypertensive medications used in everyday practice, PP decrease may be achieved best with ARBs and calcium antagonists.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0950-9240
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
765-71
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pubmed:meshHeading |
pubmed-meshheading:16855624-Adult,
pubmed-meshheading:16855624-Aged,
pubmed-meshheading:16855624-Antihypertensive Agents,
pubmed-meshheading:16855624-Blood Pressure,
pubmed-meshheading:16855624-Female,
pubmed-meshheading:16855624-Heart Ventricles,
pubmed-meshheading:16855624-Humans,
pubmed-meshheading:16855624-Hypertension,
pubmed-meshheading:16855624-Male,
pubmed-meshheading:16855624-Middle Aged,
pubmed-meshheading:16855624-Pulse,
pubmed-meshheading:16855624-Retrospective Studies
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pubmed:year |
2006
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pubmed:articleTitle |
Differential pulse pressure response to various antihypertensive drug families.
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pubmed:affiliation |
1st Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece. eva_karpanou@mailbox.gr
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pubmed:publicationType |
Journal Article,
Comparative Study
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