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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-7-18
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pubmed:abstractText |
Hypertension is a life-threatening disease that is associated with increased cardiovascular risks. Causes and mechanisms for hypertension development remain poorly understood. Methylglyoxal (MG), a highly reactive molecule, is a metabolite of sugar. Increased circulation and tissue levels of MG have been documented not only in diabetes but also in hypertension. Many recent studies also link MG-induced vascular damage to the pathogenic process of hypertension. As such, an etiological role of MG in hypertension development is proposed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-4212
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-39
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16845897-Animals,
pubmed-meshheading:16845897-Glucose,
pubmed-meshheading:16845897-Humans,
pubmed-meshheading:16845897-Hypertension,
pubmed-meshheading:16845897-Hypertrophy,
pubmed-meshheading:16845897-Mitogen-Activated Protein Kinases,
pubmed-meshheading:16845897-Muscle, Smooth, Vascular,
pubmed-meshheading:16845897-NF-kappa B,
pubmed-meshheading:16845897-Pyruvaldehyde,
pubmed-meshheading:16845897-Reactive Oxygen Species
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pubmed:year |
2006
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pubmed:articleTitle |
Is methylglyoxal a causative factor for hypertension development?
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pubmed:affiliation |
Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada. liw070@duke.usask.ca
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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