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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-1-22
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pubmed:abstractText |
To clarify the relationship between amyloid formation and amyloid precursor protein (APP), the brain sections from eight patients with Alzheimer's disease (AD) and four with Gerstmann-Sträussler Syndrome (GSS) were investigated immunohistochemically by the double-immunostaining method. In AD, most APP-positive senile plaques belong to classical plaques or primitive plaques, whereas in diffuse plaques, APP-positive neuritic components are rarely observed. The authors documented that anti-APP-labeled degenerative neurites surrounding kuru plaques in all four GSS patients. These kuru plaques were verified by double immunostaining using anti-prion protein and anti-APP. The APP-positive structures in kuru plaques were almost identical with those seen in the classical plaques in AD. The authors concluded that APP-positive degenerative neurites are not an early event in the amyloid formation of senile plaques. It is therefore postulated that depositions of beta/A4 and prion proteins are primary events that may involve the surrounding microenvironment and result in the secondary formation of APP-positive degenerative neurites, not specific to AD.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-1679596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-1689489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-1690426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-1704190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-1903170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-1977900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2058362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2110847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2117395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2180366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2441141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2464938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2473275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2476128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2502927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2503790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2649245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2657471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2668786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2675616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2859120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2864910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2881207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-2893289,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-5707082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-6182185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-6375662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684265-6801762
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1245-50
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
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pubmed:year |
1991
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pubmed:articleTitle |
Alzheimer's amyloid precursor protein-positive degenerative neurites exist even within kuru plaques not specific to Alzheimer's disease.
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pubmed:affiliation |
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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