Source:http://linkedlifedata.com/resource/pubmed/id/16839841
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2006-7-14
|
| pubmed:abstractText |
The aim of this study was to examine the effects of a 6-month intensive lifestyle modification intervention on metabolic parameters and carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus. Fifty-eight subjects with type 2 diabetes mellitus were randomly assigned to the intervention group or the control group. The subjects in the intervention group participated in a 16-week intensive lifestyle modification program and subsequent monthly meetings during the 6-month study period. Control subjects received basic dietary education and usual care. Anthropometric data, metabolic parameters, and carotid IMT were examined before the intervention and after 6 months. Lifestyle modification intervention group patients showed a significant reduction in HbA1c (-1.0% +/- 1.3% vs +0.1% +/- 1.2%, P = .002), fasting blood glucose (-1.6 +/- 1.5 vs +0.3 +/- 2.5 mmol/L, P = .001), and 2-hour postprandial plasma glucose (-2.1 +/- 2.5 vs +0.8 +/- 4.4 mmol/L, P = .003) compared with control patients after 6 months. Body weight (-2.0 +/- 2.6 vs +0.2 +/- 1.7 kg, P = .001), body mass index (-0.8 +/- 1.0 vs 0.0 +/- 0.8 kg/m2, P = .003), and systolic blood pressure (-8.2 +/- 15.9 vs +0.4 +/- 14.1 mm Hg, P = .041) were significantly decreased in the intervention group. A significantly reduced carotid mean IMT progression was seen in the intervention group after 6 months (-0.040 +/- 0.136 vs +0.083 +/- 0.167 mm, P = .007). Changes in HbA1c (r = 0.34, P = .028), fasting plasma glucose (r = 0.31, P = .045), and 2-hour postprandial plasma glucose (r = 0.37, P = .015) correlated with the mean carotid IMT change after adjustment for age and sex. In conclusion, a 6-month intensive lifestyle modification intervention in patients with type 2 diabetes mellitus resulted in improved glycemic control and decreased progression of carotid IMT.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0026-0495
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1053-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16839841-Aged,
pubmed-meshheading:16839841-Anthropometry,
pubmed-meshheading:16839841-Behavior Therapy,
pubmed-meshheading:16839841-Blood Glucose,
pubmed-meshheading:16839841-Blood Pressure,
pubmed-meshheading:16839841-Body Weight,
pubmed-meshheading:16839841-Carotid Arteries,
pubmed-meshheading:16839841-Diabetes Mellitus, Type 2,
pubmed-meshheading:16839841-Diet,
pubmed-meshheading:16839841-Dyslipidemias,
pubmed-meshheading:16839841-Echocardiography,
pubmed-meshheading:16839841-Exercise,
pubmed-meshheading:16839841-Female,
pubmed-meshheading:16839841-Humans,
pubmed-meshheading:16839841-Hypoglycemic Agents,
pubmed-meshheading:16839841-Life Style,
pubmed-meshheading:16839841-Male,
pubmed-meshheading:16839841-Middle Aged,
pubmed-meshheading:16839841-Obesity,
pubmed-meshheading:16839841-Patient Compliance,
pubmed-meshheading:16839841-Treatment Outcome
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Effects of lifestyle modification on metabolic parameters and carotid intima-media thickness in patients with type 2 diabetes mellitus.
|
| pubmed:affiliation |
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
|
| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|