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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-7-14
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pubmed:abstractText |
The MS4A2 gene, the beta chain of the high-affinity receptor for immunoglobulin (Ig)E, has previously been linked to atopy and asthma. The beta-chain of FcepsilonR1 enhances receptor maturation and signal transduction capacity, leading to the release of proinflammatory mediators and cytokines that can exacerbate the symptom of asthma. This study was performed to evaluate whether two genetic polymorphisms of the FcepsilonR1beta gene (FcepsilonR1beta-109T > C and FcepsilonR1beta E237G) are associated with aspirin-intolerant asthma (AIA). The MS4A2 gene polymorphisms (FcepsilonR1beta-109T > C and FcepsilonR1beta E237G) were determined by SNP-IT assays in patients with AIA (N = 164), aspirin-tolerant asthma (ATA, N = 144) and normal controls (NC, N = 264) recruited from a Korean population.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/MS4A2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/Superantigens,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin B, staphylococcal
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0954-7894
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
877-83
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pubmed:meshHeading |
pubmed-meshheading:16839402-Adult,
pubmed-meshheading:16839402-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:16839402-Antibodies, Bacterial,
pubmed-meshheading:16839402-Aspirin,
pubmed-meshheading:16839402-Asthma,
pubmed-meshheading:16839402-Bronchial Provocation Tests,
pubmed-meshheading:16839402-Enterotoxins,
pubmed-meshheading:16839402-Female,
pubmed-meshheading:16839402-Gene Frequency,
pubmed-meshheading:16839402-Genetic Predisposition to Disease,
pubmed-meshheading:16839402-Genotype,
pubmed-meshheading:16839402-Humans,
pubmed-meshheading:16839402-Immunoglobulin E,
pubmed-meshheading:16839402-Male,
pubmed-meshheading:16839402-Middle Aged,
pubmed-meshheading:16839402-Polymorphism, Genetic,
pubmed-meshheading:16839402-Receptors, IgE,
pubmed-meshheading:16839402-Staphylococcus aureus,
pubmed-meshheading:16839402-Superantigens
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pubmed:year |
2006
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pubmed:articleTitle |
A polymorphism of MS4A2 (- 109T > C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma.
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pubmed:affiliation |
Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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