Source:http://linkedlifedata.com/resource/pubmed/id/16825422
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2006-10-9
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| pubmed:abstractText |
The present study determined whether early loss of estrogen influences salt-sensitive changes in blood pressure, renal injury, and cardiac hypertrophy as well as the effects on the circulating renin-angiotensin-aldosterone system (RAAS) in the hypertensive female mRen(2). Lewis strain. Ovariectomy (OVX) of heterozygous mRen(2). Lewis rats on a normal salt (NS) diet (0.5% sodium) increased systolic blood pressure from 137+/-3 to 177+/-5 mmHg (P<0.01) by 15 wk but did not show any changes in cardiac-to-body weight index (CI), proteinuria, or creatinine clearance. Maintenance with a high-sodium (HS) diet (4%) increased blood pressure (203+/-4 mmHg, P<0.01), proteinuria (3.5+/-0.3 vs. 6.4+/-0.7 mg/day, P<0.05), and CI (4.0+/-0.1 vs. 5.2+/-0.1 mg/kg, P<0.01) but decreased creatinine clearance (0.89+/-0.15 vs. 0.54+/-0.06 ml/min, P<0.05). OVX exacerbated the effects of salt on the degree of hypertension (230+/-5 mmHg), CI (5.6+/-0.2 mg/kg), and proteinuria (13+/-3.0 mg/day). OVX increased the urinary excretion of aldosterone approximately twofold in animals on the NS diet (3.8+/-0.5 vs. 6.6+/-0.5 ng.mg creatinine-1.day-1, P<0.05) and HS diet (1.4+/-0.2 vs. 4.5+/-1.0 ng.mg creatinine-1.day-1, P<0.05). Circulating renin, angiotensin-converting enzyme, and angiotensin II were also significantly increased in the OVX group fed a HS diet. These results reveal that the protective effects of estrogen apart from the increase in blood pressure were only manifested in the setting of a chronic HS diet and suggest that the underlying sodium status may have an important influence on the overall effect of reduced estrogen.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride, Dietary
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0363-6119
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
291
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
R1557-63
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| pubmed:dateRevised |
2009-11-3
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| pubmed:meshHeading |
pubmed-meshheading:16825422-Aldosterone,
pubmed-meshheading:16825422-Angiotensin II,
pubmed-meshheading:16825422-Animals,
pubmed-meshheading:16825422-Blood Pressure,
pubmed-meshheading:16825422-Cardiomegaly,
pubmed-meshheading:16825422-Estrogens,
pubmed-meshheading:16825422-Female,
pubmed-meshheading:16825422-Gene Expression Regulation,
pubmed-meshheading:16825422-Heart Rate,
pubmed-meshheading:16825422-Hypertension,
pubmed-meshheading:16825422-Kidney Diseases,
pubmed-meshheading:16825422-Ovariectomy,
pubmed-meshheading:16825422-Peptidyl-Dipeptidase A,
pubmed-meshheading:16825422-Rats,
pubmed-meshheading:16825422-Rats, Inbred Lew,
pubmed-meshheading:16825422-Renin,
pubmed-meshheading:16825422-Renin-Angiotensin System,
pubmed-meshheading:16825422-Sodium Chloride, Dietary
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| pubmed:year |
2006
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| pubmed:articleTitle |
Estrogen and salt sensitivity in the female mRen(2). Lewis rat.
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| pubmed:affiliation |
Hypertension and Vascular Disease Center, Wake Forest Univ. Health Sciences, Medical Center Blvd., Winston-Salem, North Carolina 27157-1095, USA. mchappel@wfubmc.edu
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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