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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-7-25
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pubmed:abstractText |
Hepatic stellate cell (HSC) activation is a key event in wound healing as well as in fibrosis development in the liver. Previously we developed a technique to induce HSC activation in slices from rat liver. Although this model provides a physiologic, multicellular milieu that is not present in current in vitro models it might still be of limited predictive value for the human situation due to species-differences. Therefore, we now aimed to evaluate the applicability of human liver slices for the study of HSC activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-2797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
62-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16815347-Carbon Tetrachloride,
pubmed-meshheading:16815347-Cell Survival,
pubmed-meshheading:16815347-HSP47 Heat-Shock Proteins,
pubmed-meshheading:16815347-Hepatocytes,
pubmed-meshheading:16815347-Humans,
pubmed-meshheading:16815347-Liver,
pubmed-meshheading:16815347-Models, Biological,
pubmed-meshheading:16815347-RNA, Messenger,
pubmed-meshheading:16815347-alpha-Crystallin B Chain
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pubmed:year |
2006
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pubmed:articleTitle |
Human liver slices as an in vitro model to study toxicity-induced hepatic stellate cell activation in a multicellular milieu.
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pubmed:affiliation |
Department of Pharmacokinetics and Drug Delivery, University Center for Pharmacy, Groningen, The Netherlands. M.van.de.Bovenkamp@rug.nl
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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