rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
2006-8-7
|
pubmed:abstractText |
To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0364-5134
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
60
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
145-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:16802294-Aged,
pubmed-meshheading:16802294-Alzheimer Disease,
pubmed-meshheading:16802294-Amyloid,
pubmed-meshheading:16802294-Aniline Compounds,
pubmed-meshheading:16802294-Atrophy,
pubmed-meshheading:16802294-Brain,
pubmed-meshheading:16802294-Carbon Radioisotopes,
pubmed-meshheading:16802294-Cohort Studies,
pubmed-meshheading:16802294-Female,
pubmed-meshheading:16802294-Humans,
pubmed-meshheading:16802294-Magnetic Resonance Imaging,
pubmed-meshheading:16802294-Male,
pubmed-meshheading:16802294-Middle Aged,
pubmed-meshheading:16802294-Positron-Emission Tomography,
pubmed-meshheading:16802294-Thiazoles
|
pubmed:year |
2006
|
pubmed:articleTitle |
Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study.
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pubmed:affiliation |
Institute of Neurology, Dementia Research Centre, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|