Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
27
pubmed:dateCreated
2006-7-6
pubmed:abstractText
Small GTPases of the Rho family play key roles in the formation of neuronal axons and dendrites by transducing signals from guidance cues, such as neurotrophins, to the actin cytoskeleton. However, there is little insight into the mechanism by which neurotrophins regulate Rho GTPases. Here, we show the crucial role of the ubiquitous Rac1-specific guanine nucleotide exchange factor, Tiam1 (T lymphoma invasion and metastasis 1), in transducing a neurotrophin-mediated change in cell shape. We demonstrate that BDNF, acting through TrkB, directly binds and specifically activates Tiam1 by phosphorylating Tyr-829, leading to Rac1 activation and lamellipodia formation in Cos-7 cells and increased neurite outgrowth from cortical neurons. A point mutation in Tiam1, Tyr-829 to Phe-829, blocked these BDNF-induced changes in cellular morphology. The findings are evidence of a previously uncharacterized mechanism for the activation of Tiam1 and of a role for this effector in neurotrophin-mediated signal transduction leading to changes in cellular morphology.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-10224076, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-10872457, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-11257905, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-11264310, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-11520933, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-11559894, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-11707441, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-11978834, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-12221096, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-12389031, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-12478284, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-12500314, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-12510192, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-12546821, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-12676795, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-12771149, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-12829230, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-14994343, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-15138270, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-15688002, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-15721239, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-15758069, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-16203995, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-3275466, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-7731688, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-7999144, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-9348295, http://linkedlifedata.com/resource/pubmed/commentcorrection/16801538-9353304
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10444-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.
pubmed:affiliation
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. yukim@nch.go.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural