Source:http://linkedlifedata.com/resource/pubmed/id/16797783
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2006-8-15
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pubmed:abstractText |
Bradykinin related peptides (BRPs) present in the water-soluble secretion and freshly dissected skin fragments of Phyllomedusa hypochondrialis were investigated by mass spectrometry techniques. Eighteen BRPs, along with their post-translational modifications, were characterized in the secretion by de novo MS/MS sequencing and direct MALDI imaging experiments of the frog skin. These molecules revealed strong sequence similarities to the main plasma kinin of some mammals and reptiles. Such a diversity of molecules, within the same peptide family, belonging to a single amphibian species may be related to functional specializations of these peptides and a variety of corresponding receptors that might be present in a number of different predators. Also, a novel analog, [Val]1,[Thr]6-bradykinyl-Gln,Ser had its biological activity positively detected in cell culture expressing the human bradykinin B2 receptor and in guinea pig ileum preparations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0196-9781
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pubmed:author |
pubmed-author:BlochCCJr,
pubmed-author:BrandG DGD,
pubmed-author:Costa-NetoC MCM,
pubmed-author:KrauseF CFC,
pubmed-author:LeiteJ R S AJR,
pubmed-author:MeloJ A TJA,
pubmed-author:NakaieC RCR,
pubmed-author:PesqueroJ BJB,
pubmed-author:PratesM VMV,
pubmed-author:SantosE LEL,
pubmed-author:SilvaL PLP
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2137-46
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16797783-Amino Acid Sequence,
pubmed-meshheading:16797783-Animals,
pubmed-meshheading:16797783-Bradykinin,
pubmed-meshheading:16797783-CHO Cells,
pubmed-meshheading:16797783-Cricetinae,
pubmed-meshheading:16797783-Cricetulus,
pubmed-meshheading:16797783-Female,
pubmed-meshheading:16797783-Guinea Pigs,
pubmed-meshheading:16797783-Humans,
pubmed-meshheading:16797783-Hydroxyproline,
pubmed-meshheading:16797783-Mass Spectrometry,
pubmed-meshheading:16797783-Molecular Sequence Data,
pubmed-meshheading:16797783-Muscle, Smooth,
pubmed-meshheading:16797783-Ranidae,
pubmed-meshheading:16797783-Receptor, Bradykinin B2,
pubmed-meshheading:16797783-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:16797783-Transfection
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pubmed:year |
2006
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pubmed:articleTitle |
Bradykinin-related peptides from Phyllomedusa hypochondrialis.
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pubmed:affiliation |
Laboratório de Espectrometria de Massa, EMBRAPA, Recursos Genéticos e Biotecnologia, Brasília, DF 70770-900, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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