| pubmed-article:16794737 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16794737 | lifeskim:mentions | umls-concept:C0036126 | lld:lifeskim |
| pubmed-article:16794737 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:16794737 | lifeskim:mentions | umls-concept:C0376659 | lld:lifeskim |
| pubmed-article:16794737 | lifeskim:mentions | umls-concept:C0011209 | lld:lifeskim |
| pubmed-article:16794737 | lifeskim:mentions | umls-concept:C1519713 | lld:lifeskim |
| pubmed-article:16794737 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:16794737 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:16794737 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16794737 | pubmed:dateCreated | 2006-7-6 | lld:pubmed |
| pubmed-article:16794737 | pubmed:abstractText | Bacterial vectors may offer many advantages over other antigen delivery systems for cancer vaccines. We engineered a Salmonella typhimurium vaccine strain to deliver the NY-ESO-1 tumor antigen (S. typhimurium-NY-ESO-1) through a type III protein secretion system. The S. typhimurium-NY-ESO-1 construct elicited NY-ESO-1-specific CD8+ and CD4+ T cells from peripheral blood lymphocytes of cancer patients in vitro. Oral administration of S. typhimurium-NY-ESO-1 to mice resulted in the regression of established NY-ESO-1-expressing tumors. Intratumoral inoculation of S. typhimurium-NY-ESO-1 to NY-ESO-1-negative tumors resulted in delivery of antigen in vivo and led to tumor regression in the presence of preexisting NY-ESO-1-specific CD8+ T cells. Specific T cell responses against at least 2 unrelated tumor antigens not contained in the vaccine were observed, demonstrating epitope spreading. We propose that antigen delivery through the S. typhimurium type III secretion system is a promising novel strategy for cancer vaccine development. | lld:pubmed |
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| pubmed-article:16794737 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16794737 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16794737 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16794737 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16794737 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16794737 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:JägerElkeE | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:ChenLi-MeiLM | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:NomuraHidekiH | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:ShikuHiroshiH | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:GalánJorge... | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:OldLloyd JLJ | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:RitterGerdG | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:NishikawaHiro... | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:SatoEiichiE | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:NagataYasuhir... | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:MatsuoMitsuto... | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:GnjaticSachaS | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:KatoTakumaT | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:TawaraIsaoI | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:BrionesGabrie... | lld:pubmed |
| pubmed-article:16794737 | pubmed:author | pubmed-author:KondoShigetoS | lld:pubmed |
| pubmed-article:16794737 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16794737 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:16794737 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16794737 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16794737 | pubmed:pagination | 1946-54 | lld:pubmed |
| pubmed-article:16794737 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16794737 | pubmed:meshHeading | pubmed-meshheading:16794737... | lld:pubmed |
| pubmed-article:16794737 | pubmed:meshHeading | pubmed-meshheading:16794737... | lld:pubmed |
| pubmed-article:16794737 | pubmed:meshHeading | pubmed-meshheading:16794737... | lld:pubmed |
| pubmed-article:16794737 | pubmed:meshHeading | pubmed-meshheading:16794737... | lld:pubmed |
