|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2006-7-6
|
|
pubmed:abstractText |
Bacterial vectors may offer many advantages over other antigen delivery systems for cancer vaccines. We engineered a Salmonella typhimurium vaccine strain to deliver the NY-ESO-1 tumor antigen (S. typhimurium-NY-ESO-1) through a type III protein secretion system. The S. typhimurium-NY-ESO-1 construct elicited NY-ESO-1-specific CD8+ and CD4+ T cells from peripheral blood lymphocytes of cancer patients in vitro. Oral administration of S. typhimurium-NY-ESO-1 to mice resulted in the regression of established NY-ESO-1-expressing tumors. Intratumoral inoculation of S. typhimurium-NY-ESO-1 to NY-ESO-1-negative tumors resulted in delivery of antigen in vivo and led to tumor regression in the presence of preexisting NY-ESO-1-specific CD8+ T cells. Specific T cell responses against at least 2 unrelated tumor antigens not contained in the vaccine were observed, demonstrating epitope spreading. We propose that antigen delivery through the S. typhimurium type III secretion system is a promising novel strategy for cancer vaccine development.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-10371507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-10566144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-10781081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-10969798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-11005863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-11351307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-11672924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-11687484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-11724951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-11910899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-12080382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-12370380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-12445281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-12479820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-12532024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-12551977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-12853579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-12918057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-12947044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-1377368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-14636560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-14738373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-14756788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-14981514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15036140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15064759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15340416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15375003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15454922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15539158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15644448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15657293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15657294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-15867392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-16061876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-16123302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-1624429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-16306269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-1660837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-197192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-2227450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-2671582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-3929396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-8289811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-8522512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-8524854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-9050879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-9177225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-9432985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794737-9677200
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0021-9738
|
|
pubmed:author |
pubmed-author:BrionesGabrielG,
pubmed-author:ChenLi-MeiLM,
pubmed-author:GalánJorge EJE,
pubmed-author:GnjaticSachaS,
pubmed-author:JägerElkeE,
pubmed-author:KatoTakumaT,
pubmed-author:KondoShigetoS,
pubmed-author:MatsuoMitsutoshiM,
pubmed-author:NagataYasuhiroY,
pubmed-author:NishikawaHiroyoshiH,
pubmed-author:NomuraHidekiH,
pubmed-author:OldLloyd JLJ,
pubmed-author:RitterGerdG,
pubmed-author:SatoEiichiE,
pubmed-author:ShikuHiroshiH,
pubmed-author:TawaraIsaoI
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
116
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1946-54
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
