Source:http://linkedlifedata.com/resource/pubmed/id/16788687
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2006-8-10
|
| pubmed:abstractText |
Cardiovascular mortality is increased in transplant recipients. However, studies including non-fatal events are critical to assess the burden of disease and to identify novel risk factors. We described the incidence of fatal and non-fatal events, and explored associations and interactions among traditional and transplant-specific risk factors and cardiovascular events (CVE) in a cohort of 922 patients transplanted between 1993 and 1998. One hundred and seventy-six patients experienced 201 CVE (111 cardiac, 48 cerebrovascular, 42 peripheral-vascular). Most CVE were non-fatal. Factors associated with cardiac events were (adjusted hazard ratios) tobacco (3.53; P<0.001), obesity (2.92; P<0.001), diabetes (2.63; P<0.001), multiple rejections (2.19; P=0.008), prior CVE (2.0; P=0.004), dialysis >1 year (1.91; P=0.007), and overweight status (1.68; P=0.04); with cerebrovascular events: diabetes and peritoneal dialysis (11.95; P<0.001), age >45 (6.77; P<0.001), diabetes (4.87; P<0.001), prior CVE (3.73; P<0.001), creatinine >141 micromol/l (3.16; P=0.001), peritoneal dialysis (3.06; P=0.027), and obesity (0.32; P=0.046); with peripheral-vascular events: diabetes (8.48; P<0.001), tobacco and cytomegalovirus (3.88; P<0.001), age >45 (2.31; P=0.019), and prior CVE (2.25; P=0.016); with mortality: tobacco and deceased-donor (3.52; P<0.001), age >45 (1.81; P=0.002), diabetes (1.76; P=0.002), pulse pressure (1.64; P=0.029), prior CVE (1.52; P=0.04), and dialysis >1 year (1.47; P=0.04). The majority of CVE post-transplant were non-fatal. Previous CVE was strongly associated with CVE post-transplant. Interactions among transplant-specific and traditional risks impacted significantly the incidence of CVE. Modifiable factors such as duration of dialysis, deceased-donor transplantation, and acute rejection should be viewed as cardiovascular risks.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0085-2538
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
757-64
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16788687-Adolescent,
pubmed-meshheading:16788687-Adult,
pubmed-meshheading:16788687-Cytomegalovirus Infections,
pubmed-meshheading:16788687-Female,
pubmed-meshheading:16788687-Graft Rejection,
pubmed-meshheading:16788687-Humans,
pubmed-meshheading:16788687-Incidence,
pubmed-meshheading:16788687-Kidney Transplantation,
pubmed-meshheading:16788687-Male,
pubmed-meshheading:16788687-Middle Aged,
pubmed-meshheading:16788687-Myocardial Infarction,
pubmed-meshheading:16788687-Peripheral Vascular Diseases,
pubmed-meshheading:16788687-Postoperative Complications,
pubmed-meshheading:16788687-Prospective Studies,
pubmed-meshheading:16788687-Renal Dialysis,
pubmed-meshheading:16788687-Risk Factors,
pubmed-meshheading:16788687-Stroke,
pubmed-meshheading:16788687-Tissue Donors
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Cardiovascular events following renal transplantation: role of traditional and transplant-specific risk factors.
|
| pubmed:affiliation |
Transplantation Medicine Program, Oregon Health and Science University, Portland, Oregon, USA. demattos@uab.edu
|
| pubmed:publicationType |
Journal Article
|