Source:http://linkedlifedata.com/resource/pubmed/id/16783848
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2006-8-7
|
| pubmed:abstractText |
Trichinella spiralis and Trichuris muris are nematode parasites of the mouse, dwelling in the small and large intestines, respectively: worm expulsion requires development of a Th2 immune response. The chemokine CCL11 is agonist for the chemokine receptor CCR3 and acts in synergy with IL-5 to recruit eosinophils to inflammatory sites. The role of CCL11 in gastrointestinal helminth infection has not been previously studied. We challenged wild-type (WT) BALB/c, CCL11 single knockout (SKO) and CCL11 IL-5 double knockout (DKO) mice with either T. spiralis muscle larvae or T. muris eggs in order to examine eosinophil recruitment to the small and large intestine during helminth infection. A peripheral eosinophilia was seen in WT and SKO mice during T. spiralis infection but not with T. muris. Gastrointestinal eosinophilia was markedly reduced but not ablated in SKO mice -- and negligible in DKO mice -- infected with either nematode. The residual eosinophilia and up-regulation of CCL24 mRNA in the gastrointestinal tract of SKO mice infected with either nematode, together with the presence of an eosinophil-active factor in T. spiralis and T. muris products, suggest that CCL11 is the salient but not the sole eosinophil chemoattractant of biological significance during gastrointestinal helminth infection.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ccl11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL11,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0014-2980
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1753-63
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:16783848-Animals,
pubmed-meshheading:16783848-Cell Movement,
pubmed-meshheading:16783848-Cells, Cultured,
pubmed-meshheading:16783848-Chemokine CCL11,
pubmed-meshheading:16783848-Chemokines, CC,
pubmed-meshheading:16783848-Cytokines,
pubmed-meshheading:16783848-Eosinophils,
pubmed-meshheading:16783848-Gastric Mucosa,
pubmed-meshheading:16783848-Interleukin-15,
pubmed-meshheading:16783848-Intestinal Mucosa,
pubmed-meshheading:16783848-Male,
pubmed-meshheading:16783848-Mice,
pubmed-meshheading:16783848-Mice, Inbred BALB C,
pubmed-meshheading:16783848-Mice, Knockout,
pubmed-meshheading:16783848-Th2 Cells,
pubmed-meshheading:16783848-Trichinella spiralis,
pubmed-meshheading:16783848-Trichinellosis,
pubmed-meshheading:16783848-Trichuriasis,
pubmed-meshheading:16783848-Trichuris
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection.
|
| pubmed:affiliation |
Faculty of Life Sciences, University of Manchester, Manchester, UK. helen.dixon@manchester.ac.uk
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|