Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2006-6-15
pubmed:abstractText
Efficient expression of the adeno-associated virus type 5 (AAV5) P41 capsid gene promoter required adenovirus E1A and/or E1B; however, in contrast to what was observed for expression of the AAV2 capsid gene promoter (P40), neither adenovirus infection nor the large Rep protein was required. Although both the AAV2 and the AAV5 large Rep proteins efficiently bound the (GAGY)(3) Rep-binding element, the AAV5 large Rep protein transactivated transcription of the inducible AAV2 P40 promoter much less well than AAV2 large Rep. Differences in their activation potentials were mapped to the amino-terminal region of the proteins, and the poorly transactivating AAV5 Rep protein could competitively inhibit AAV2 Rep transactivation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-10196327, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-10666268, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-11024114, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-11997501, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-12191478, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-12438569, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-1318396, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-14967147, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-1592259, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-16378968, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-16415037, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-1825251, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-8380475, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-8389942, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-8642672, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-9151818, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-9261378, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-9261407, http://linkedlifedata.com/resource/pubmed/commentcorrection/16775342-9420229
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6559-67
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Efficient expression of the adeno-associated virus type 5 p41 capsid gene promoter in 293 cells does not require Rep.
pubmed:affiliation
Department of Molecular Microbiology and Immunology, 471f Life Sciences Center, University of Missouri-Columbia, 1201 Rollins Road, Columbia, MO 65211, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural