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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-6-14
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pubmed:abstractText |
Bisphosphonates are well established for the management of cancer-induced skeletal complications. Recent studies suggest that bisphosphonates promote apoptosis of cancer cells as well as osteoclasts in bone metastatic sites. To determine the direct effects of bisphosphonate on prostate cancer, we examined the effects of minodronate on prostatic cancer cell growth and the expression of apoptosis-related proteins and osteoclastogenic factors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0919-8172
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-600
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16771731-Apoptosis,
pubmed-meshheading:16771731-Caspase 3,
pubmed-meshheading:16771731-Cell Line, Tumor,
pubmed-meshheading:16771731-Cytokines,
pubmed-meshheading:16771731-Diphosphonates,
pubmed-meshheading:16771731-Gene Expression,
pubmed-meshheading:16771731-Growth Substances,
pubmed-meshheading:16771731-Humans,
pubmed-meshheading:16771731-Inhibitory Concentration 50,
pubmed-meshheading:16771731-Male,
pubmed-meshheading:16771731-Osteoclasts,
pubmed-meshheading:16771731-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:16771731-Prostatic Neoplasms,
pubmed-meshheading:16771731-Proto-Oncogene Proteins c-bcl-2
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pubmed:year |
2006
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pubmed:articleTitle |
Bisphosphonate induces apoptosis and inhibits pro-osteoclastic gene expression in prostate cancer cells.
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pubmed:affiliation |
Department of Urology, School of Medicine, Kanazawa University, Kanazawa, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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