|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2006-6-12
|
|
pubmed:abstractText |
Protein-based polymers are water soluble at lower temperatures but undergo a phase transition with increasing temperature. The polymers' hydrophobicity controls the transition temperature and the free energy of its charged groups through an apolar-polar repulsive free energy of hydration, which drives the binding of charged drugs. Binding and release of phosphorothioates were obtained with polymers containing 1 lysine alone or coupled with 2 to 5 phenylalanines per 30 residues. Release rates from 4 to 64 nmol/ cm2/day were maintained constant for 8 to 2 weeks/mm, respectively. We demonstrated the ability of protein-based polymers to deliver nucleic acid based therapeutics with high programmability.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1071-7544
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
253-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16766466-Delayed-Action Preparations,
pubmed-meshheading:16766466-Lysine,
pubmed-meshheading:16766466-Oligonucleotides, Antisense,
pubmed-meshheading:16766466-Phenylalanine,
pubmed-meshheading:16766466-Phosphates,
pubmed-meshheading:16766466-Polymers,
pubmed-meshheading:16766466-Recombinant Proteins,
pubmed-meshheading:16766466-Solubility,
pubmed-meshheading:16766466-Structure-Activity Relationship,
pubmed-meshheading:16766466-Transition Temperature
|
|
pubmed:articleTitle |
Controlled release of phosphorothioates by protein-based polymers.
|
|
pubmed:affiliation |
Bioelastics, Inc., Vestavia Hills, Alabama, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|
