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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021368,
umls-concept:C0032615,
umls-concept:C0185117,
umls-concept:C0205314,
umls-concept:C0344315,
umls-concept:C0521447,
umls-concept:C0663914,
umls-concept:C0679622,
umls-concept:C1424976,
umls-concept:C1521761,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2006-7-7
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pubmed:abstractText |
Several novel polyunsaturated fatty acids (PUFAs) that contain either an oxygen or sulfur atom in the beta-position were found to exhibit more selective antiinflammatory properties than their natural PUFA counterparts. One of these, beta-oxa-23:4n-6, unlike natural PUFAs, lacked ability to stimulate oxygen radical production in neutrophils but caused marked inhibition of agonist-induced upregulation of leukocyte adhesion to cultured human umbilical vein endothelial cells (HUVEC) and E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 expression. In addition, beta-oxa-23:4n-6 inhibited acute and chronic inflammatory responses in mice as well as the upregulation of adhesion molecule expression in arterial endothelium. This action of beta-oxa-23:4n-6 required a functional 12- but not 5-lipoxygenase or cyclooxygenases, consistent with its metabolism via the 12-lipoxygenase pathway. Whereas beta-oxa-23:4n-6 did not affect the activation of mitogen-activated protein kinases by tumor necrosis factor, activation of the IkappaB kinase/nuclear factor kappaB pathway was selectively inhibited. These novel PUFAs could form the basis for a potential new class of pharmaceuticals for treating inflammatory diseases, including atherosclerosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4571
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pubmed:author |
pubmed-author:EastonChristopher JCJ,
pubmed-author:FerranteAntonioA,
pubmed-author:FerranteJudith VJV,
pubmed-author:HiiCharles S TCS,
pubmed-author:HuangZhi HZH,
pubmed-author:JersmannHubertus P AHP,
pubmed-author:LeeFrank SFS,
pubmed-author:PittMichael JMJ,
pubmed-author:PoulosAlfA,
pubmed-author:PragerRolf HRH,
pubmed-author:RathjenDeborah ADA,
pubmed-author:RobinsonBrenton SBS,
pubmed-author:SinghHarmeetH,
pubmed-author:TroutNeil ANA
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pubmed:issnType |
Electronic
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pubmed:day |
7
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16763165-Animals,
pubmed-meshheading:16763165-Anti-Inflammatory Agents,
pubmed-meshheading:16763165-Arachidonate 12-Lipoxygenase,
pubmed-meshheading:16763165-Cell Adhesion,
pubmed-meshheading:16763165-Cells, Cultured,
pubmed-meshheading:16763165-Down-Regulation,
pubmed-meshheading:16763165-Endothelial Cells,
pubmed-meshheading:16763165-Fatty Acids, Unsaturated,
pubmed-meshheading:16763165-Humans,
pubmed-meshheading:16763165-I-kappa B Kinase,
pubmed-meshheading:16763165-Intercellular Adhesion Molecule-1,
pubmed-meshheading:16763165-Mice,
pubmed-meshheading:16763165-Mice, Inbred BALB C,
pubmed-meshheading:16763165-Monocytes,
pubmed-meshheading:16763165-NF-kappa B,
pubmed-meshheading:16763165-Neutrophils,
pubmed-meshheading:16763165-Respiratory Burst,
pubmed-meshheading:16763165-Signal Transduction,
pubmed-meshheading:16763165-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16763165-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2006
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pubmed:articleTitle |
A novel beta-oxa polyunsaturated fatty acid downregulates the activation of the IkappaB kinase/nuclear factor kappaB pathway, inhibits expression of endothelial cell adhesion molecules, and depresses inflammation.
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pubmed:affiliation |
Department of Immunopathology, Women's and Children's Hospital, University of Adelaide, South Australia, Australia. antonio.ferrante@adelaide.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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