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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5779
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pubmed:dateCreated |
2006-6-9
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pubmed:databankReference |
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pubmed:abstractText |
Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-12580282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-12624113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-12954091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-14641575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-15028675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-15385501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-15525535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-15546607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-15550247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-15972528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-16208377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-16307477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-16373506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-16432199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-16452401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-8557353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16763151-8840786
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:CuffMarianne EME,
pubmed-author:GiffordCasey ACA,
pubmed-author:GoodmanAndrew LAL,
pubmed-author:JoachimiakAndrzejA,
pubmed-author:JoachimiakGrazynaG,
pubmed-author:LoryStephenS,
pubmed-author:MekalanosJohn JJJ,
pubmed-author:MougousJoseph DJD,
pubmed-author:OrdoñezClaudia LCL,
pubmed-author:RaunserStefanS,
pubmed-author:ShenAimeeA,
pubmed-author:WalzThomasT,
pubmed-author:ZhouMinM
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
312
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1526-30
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16763151-Animals,
pubmed-meshheading:16763151-Bacterial Proteins,
pubmed-meshheading:16763151-Crystallography, X-Ray,
pubmed-meshheading:16763151-Cystic Fibrosis,
pubmed-meshheading:16763151-Humans,
pubmed-meshheading:16763151-Models, Molecular,
pubmed-meshheading:16763151-Protein Conformation,
pubmed-meshheading:16763151-Pseudomonas Infections,
pubmed-meshheading:16763151-Pseudomonas aeruginosa,
pubmed-meshheading:16763151-Rats,
pubmed-meshheading:16763151-Recombinant Fusion Proteins,
pubmed-meshheading:16763151-Sequence Alignment,
pubmed-meshheading:16763151-Virulence
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pubmed:year |
2006
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pubmed:articleTitle |
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
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pubmed:affiliation |
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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