Linked Life Data

1676176

Source:http://linkedlifedata.com/resource/pubmed/id/1676176

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-7-31
pubmed:abstractText
Mice of the two substrains AB/Gat and AB/Hal from the Jena AB inbred strain differ in behavior from each other by their aggressiveness occurring especially in the latter group after maturity. In order to ascertain the neurobiological background of aggressiveness, we injected mice of both substrains with either haloperidol, diazepam, or hexobarbital and measured their response on motor activity. In a second experiment, the reaction to a seizure evoking agent (pentylenetetrazol) was determined. Mice of both substrains were found to differ significantly in their reaction to haloperidol or diazepam injection. In contrast to that no changes in motor activity could be detected following hexobarbital administration. Animals of the aggressive AB/Hal substrain reacted more pronounced to pentylenetetrazol than those of the AB/Gat group. In conclusion, the varying aggressiveness of both AB mice substrains may be due to differences in dopaminergic and GABAergic neurotransmission.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
471-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Pharmacological effects on two inbred substrains of AB mice.
pubmed:affiliation
Institute of Pharmacology and Toxicology, Medical Academy Magdeburg, GDR.
pubmed:publicationType
Journal Article, Comparative Study