Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8758
|
| pubmed:dateCreated |
1991-7-29
|
| pubmed:commentsCorrections | |
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception Failure,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Postcoital,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Usage,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/PROBABILITY,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Progestational Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Progesterone--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Statistical Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Studies
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
338
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
39-41
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:otherAbstract |
PIP: In preparation for a clinical trial of an antiprogesterone molecule as a postcoital contraceptive method, the authors reviewed the available research on the effectiveness of use of high-dose estrogen and combined estrogen-progesterone preparations for this purpose. The medical literature for the period 1971-87 included 5 studies on the former and 5 studies on the latter regimens that involved over 500 subjects. In each of these studies, the failure rate was calculated by dividing the number of observed pregnancies by the total number of women enrolled. The authors computed true failure rates for the 10 studies in 2 different ways. First, the failure rate derived from the number of reported pregnancies was divided by the number of expected pregnancies according to Tietze's probability of pregnancy. Second, the true failure rate derived from Dixon's table was calculated. Since the latter approach requires data on the date of the intercourse that resulted in pregnancy, it could not be applied to all 10 studies. The 5 studies on the efficacy of high-dose estrogen as a postcoital contraceptive reported failure rates below 1%. However, the authors' recalculations indicated failure rates as high as 48% (Tietze) or 16% (Dixon). COmbined estrogen-progesterone was reported to produce a failure rate of 0.16-5%. Here, the true failure rate was as high as 4.2-100% (Tietze) or 5.9-44% (Dixon). The implication of these recalculations is that use of the total number of women enrolled as the denominator produces a substantially lower failure rate than the number of women potentially pregnant. Given the potential for underestimation of the efficacy of postcoital contraceptives, more prospective controlled studies are urged.
|
| pubmed:meshHeading |
pubmed-meshheading:1676094-Adolescent,
pubmed-meshheading:1676094-Adult,
pubmed-meshheading:1676094-Contraceptives, Oral, Combined,
pubmed-meshheading:1676094-Contraceptives, Postcoital, Hormonal,
pubmed-meshheading:1676094-Female,
pubmed-meshheading:1676094-Humans,
pubmed-meshheading:1676094-Meta-Analysis as Topic,
pubmed-meshheading:1676094-Middle Aged,
pubmed-meshheading:1676094-Pregnancy
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Postcoital contraception: myth or reality?
|
| pubmed:publicationType |
Journal Article,
Meta-Analysis
|