16759861

Source:http://linkedlifedata.com/resource/pubmed/id/16759861

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0020792, umls-concept:C0030004, umls-concept:C0038477, umls-concept:C0205210, umls-concept:C0243077, umls-concept:C1366876, umls-concept:C1527148, umls-concept:C1833235
pubmed:issue	16
pubmed:dateCreated	2006-7-17
pubmed:abstractText	The synthesis, structure-activity relationship, in vivo activity, and metabolic profile for a series of triazolopyridine-oxazole based p38 inhibitors are described. The deficiencies of the lead structure in the series, CP-808844, were overcome by changes to the C4 aryl group and the triazole side-chain culminating in the identification of several potential clinical candidates.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Oxazoles, http://linkedlifedata.com/resource/pubmed/chemical/Pyridines, http://linkedlifedata.com/resource/pubmed/chemical/Triazoles, http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0960-894X
pubmed:author	pubmed-author:AbramovYuriy AYA, pubmed-author:AudolyLaurentL, pubmed-author:BachJustinJ, pubmed-author:BarberiaJohn TJT, pubmed-author:BraganzaJohn FJF, pubmed-author:CarterDemetriusD, pubmed-author:CartyThomas JTJ, pubmed-author:CortinaSanto RSR, pubmed-author:DombroskiMark AMA, pubmed-author:DonahueKathleen MKM, pubmed-author:ElliottNancy CNC, pubmed-author:GabelChristopher ACA, pubmed-author:GibbonsColleen PCP, pubmed-author:JordanCrystal KCK, pubmed-author:KalgutkarAmit SAS, pubmed-author:KupermanAlexander VAV, pubmed-author:LabasiJeff MJM, pubmed-author:LairdEllen RER, pubmed-author:LaliberteRonald ERE, pubmed-author:LetavicMichael AMA, pubmed-author:LombardoFrancoF, pubmed-author:McClureKim FKF, pubmed-author:McCoyJennifer MJM, pubmed-author:NaimanBrian MBM, pubmed-author:NelsonKendra LKL, pubmed-author:NguyenHang THT, pubmed-author:PeeseKevin MKM, pubmed-author:SweeneyFrancis JFJ, pubmed-author:TaylorTimothy JTJ, pubmed-author:TrebinoCatherine ECE, pubmed-author:VolbergWalter AWA, pubmed-author:ZhouJunJ
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4339-44
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:16759861-Chemistry, Pharmaceutical, pubmed-meshheading:16759861-Drug Design, pubmed-meshheading:16759861-Enzyme Inhibitors, pubmed-meshheading:16759861-Humans, pubmed-meshheading:16759861-Inhibitory Concentration 50, pubmed-meshheading:16759861-Kinetics, pubmed-meshheading:16759861-Models, Chemical, pubmed-meshheading:16759861-Oxazoles, pubmed-meshheading:16759861-Pyridines, pubmed-meshheading:16759861-Solubility, pubmed-meshheading:16759861-Structure-Activity Relationship, pubmed-meshheading:16759861-Triazoles, pubmed-meshheading:16759861-p38 Mitogen-Activated Protein Kinases
pubmed:year	2006
pubmed:articleTitle	Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.
pubmed:affiliation	Pfizer Global Research and Development, Groton Laboratories, CT 06340, USA. kim.f.mcclure@pfizer.com
pubmed:publicationType	Journal Article