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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1991-7-24
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pubmed:abstractText |
The role of CD4+ lymphocytes in resistance of N:NIH(S) III bg/bg nu/+ mice to mucosal candidiasis was evaluated. Alimentary tract colonization with a pure culture of Candida albicans induced a population of lymphocytes in both the Peyer's patches and spleens of bg/bg nu/+ mice, but not bg/bg nu/nu mice, that proliferated and produced interleukin-2 (IL-2) in response to C. albicans antigens. The induction of candida-specific lymphocytes correlated with the clearance of C. albicans from the esophagus and tongue of resistant bg/bg nu/+ mice. Isogenic bg/bg nu/nu mice which do not develop candida-reactive lymphocytes were unable to clear C. albicans from their tongues and esophagi. Treatment of bg/bg nu/+ mice with anti-CD4+ monoclonal antibodies depleted their CD4+ lymphocytes and increased their susceptibility to mucosal candidiasis of the tongue and esophagus. In vivo treatment of bg/bg nu/+ mice with anti-IL-2, anti-gamma interferon (IFN-gamma), or both anti-IL-2 and anti-IFN-gamma monoclonal antibodies did not abrogate their resistance to mucosal candidiasis. Furthermore, treatment of C. albicans-susceptible bg/bg nu/nu mice with IFN-gamma and IL-2 did not protect them from mucosal candidiasis. Thus, CD4+ cells apparently play a critical role in resistance to mucosal candidiasis; however, we were unable to demonstrate a role for IL-2 and IFN-gamma in mediating resistance to mucosal candidiasis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-1898905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-1968080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-1971296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2105915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2108087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2145360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2180820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2403528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2419430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2498208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2499629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2512128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2562942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2564487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2570802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2572556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2573632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2642464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2661688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2960769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-2968320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-3093587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-3106216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-3139569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-3275585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-3276150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-3277917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-3494200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-3877764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-4160825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-5970461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-6372689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-6996654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1675629-7010113
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2447-55
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1675629-Animals,
pubmed-meshheading:1675629-Antibodies, Anti-Idiotypic,
pubmed-meshheading:1675629-Antibodies, Monoclonal,
pubmed-meshheading:1675629-Antigens, Fungal,
pubmed-meshheading:1675629-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1675629-Candida albicans,
pubmed-meshheading:1675629-Candidiasis,
pubmed-meshheading:1675629-Immunity, Cellular,
pubmed-meshheading:1675629-Interferon-gamma,
pubmed-meshheading:1675629-Interleukin-2,
pubmed-meshheading:1675629-Mice,
pubmed-meshheading:1675629-Mice, Nude,
pubmed-meshheading:1675629-Mucous Membrane
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pubmed:year |
1991
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pubmed:articleTitle |
Role of CD4+ lymphocytes in resistance to mucosal candidiasis.
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pubmed:affiliation |
Department of Surgery, University of Wisconsin Medical School, Madison 53706.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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