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rdf:type |
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lifeskim:mentions |
umls-concept:C0032850,
umls-concept:C0037045,
umls-concept:C0080194,
umls-concept:C0205250,
umls-concept:C0205409,
umls-concept:C0205460,
umls-concept:C0325328,
umls-concept:C0450254,
umls-concept:C0871161,
umls-concept:C1513380,
umls-concept:C1613950,
umls-concept:C1705493,
umls-concept:C2076596
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pubmed:issue |
2
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pubmed:dateCreated |
2006-6-7
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ230521,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ232605,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ232606,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ232607,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ232608,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ232609,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ232610,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ234073,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ234074,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ234075,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ234076,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ234077,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ234078
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pubmed:abstractText |
The full-size genomes of 2 highly pathogenetic avian influenza (HPAI) virus strains isolated from a wild great-crested grebe (A/Grebe/Novosibirsk/29/05) and a domestic duck (A/Duck/Novosibirsk/56/05) in the tract of the Chany hollow, Barabino forest-steppe (Novosibirsk Region) during the epizootic outbreak in the summer of 2005. The reproductive properties of these strains successively increase in the series of cell lines BHK-2 --> LEH --> Vero-E6 --> MDCK --> PS. A/Grebe/Novosibirsk/29/05 and A/Duck/Novosibirsk/56/05 were shown to be genetically close in all genomic segments to both each other and a group of HPAI/H5N1 A/Qinghai 05 strains isolated from wild birds on the Kukunor Lake in the northwestern province of Tsinkhai, China, in May 2005. All the above strains have the HPAI/H5-specific amino acid sequence of a proteolytic cleavage site (PQGERRRKKRGLF) with Lys-627 in the protein PB2 (which is associated with increased virulence to mammalian cells), Glu-92 in the protein NS1 (that suppresses an antiviral response in the host), Ser-31 in M2 (that is a marker of rimantadine/amantadine sensitivity), 20-member amino acid deletion in the protein NA (positions 49-68) that is a marker of affiliation to the so-called genotype Z and of increased tropism to poultry.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amantadine,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/M2 protein, Influenza A virus,
http://linkedlifedata.com/resource/pubmed/chemical/PA protein, influenza viruses,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Replicase,
http://linkedlifedata.com/resource/pubmed/chemical/Rimantadine,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Nonstructural Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:issn |
0507-4088
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16756172-Amantadine,
pubmed-meshheading:16756172-Amino Acid Substitution,
pubmed-meshheading:16756172-Animals,
pubmed-meshheading:16756172-Animals, Domestic,
pubmed-meshheading:16756172-Animals, Wild,
pubmed-meshheading:16756172-Antiviral Agents,
pubmed-meshheading:16756172-Birds,
pubmed-meshheading:16756172-Cell Line,
pubmed-meshheading:16756172-Cercopithecus aethiops,
pubmed-meshheading:16756172-Cricetinae,
pubmed-meshheading:16756172-Disease Outbreaks,
pubmed-meshheading:16756172-Dogs,
pubmed-meshheading:16756172-Genome, Viral,
pubmed-meshheading:16756172-Humans,
pubmed-meshheading:16756172-Influenza A Virus, H5N1 Subtype,
pubmed-meshheading:16756172-Influenza in Birds,
pubmed-meshheading:16756172-Kidney,
pubmed-meshheading:16756172-Microbial Sensitivity Tests,
pubmed-meshheading:16756172-Molecular Sequence Data,
pubmed-meshheading:16756172-Peptide Hydrolases,
pubmed-meshheading:16756172-RNA Replicase,
pubmed-meshheading:16756172-Rimantadine,
pubmed-meshheading:16756172-Siberia,
pubmed-meshheading:16756172-Species Specificity,
pubmed-meshheading:16756172-Swine,
pubmed-meshheading:16756172-Viral Matrix Proteins,
pubmed-meshheading:16756172-Viral Nonstructural Proteins,
pubmed-meshheading:16756172-Viral Proteins,
pubmed-meshheading:16756172-Virulence
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pubmed:articleTitle |
[Molecular genetic analysis of the biological properties of highly pathogenic influenza A/H5N1 virus strains isolated from wild birds and poultry during epizooty in Western Siberia (July 2005)].
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pubmed:publicationType |
Journal Article,
English Abstract
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