Linked Life Data

16749889

Source:http://linkedlifedata.com/resource/pubmed/id/16749889

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-6-5
pubmed:abstractText
Atherosclerosis is the underlying cause of most cardiovascular-related deaths in industrialized nations. Determining the etiology of atherosclerosis and detecting lesions in the early stages of the disease for possible pharmacological or mechanical intervention have been challenges facing cardiovascular researchers. In addition to genetic and environmental factors, the formation and growth of atheroma have been linked to the complex fluid dynamics and mass transport in these arterial segments. This article reviews the current state of affairs in imaging modalities and image processing techniques that allow the visualization and morphologically realistic reconstruction of coronary arterial geometry to aid in the diagnosis and treatment of coronary artery disease (CAD). In addition, studies pertaining to our current understanding of the complex flow dynamics in the coronary arteries and the relationship between fluid-induced stresses on the initiation and growth of the atherosclerotic lesions are also reviewed. The article concludes with a brief discussion on possible future directions of research that will advance our knowledge of this challenging problem.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0278-940X
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-103
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Coronary arteries: imaging, reconstruction, and fluid dynamic analysis.
pubmed:affiliation
Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, 52242-1527, USA. chandran@engineering.uiowa.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural