Linked Life Data

16749808

Source:http://linkedlifedata.com/resource/pubmed/id/16749808

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-6-5
pubmed:abstractText
The addition of a 2-silyloxy silylketene acetal to N-benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone (Mannich-type reaction) can be stereocontrolled to give 2S,3S,4S and 2R,3R,4S adducts as major compounds, depending on whether the reaction is activated with zinc(II) triflate or tin(IV) chloride, respectively. The corresponding major adducts were used for preparing diastereomeric polyhydroxy-beta-aminoesters that were further converted into suitable orthogonally protected enantiomeric D- and L-erythro-sphingosines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-3263
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4685-8
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Enantiodivergent synthesis of D- and L-erythro-sphingosines through Mannich-type reactions of N-benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone.
pubmed:affiliation
Laboratorio de Sintesis Asimetrica, Departamento de Quimica Organica, Instituto de Ciencia de Materiales de Aragon, Universidad de Zaragoza, CSIC, E-50009 Zaragoza, Aragon, Spain. pmerino@unizar.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't