Source:http://linkedlifedata.com/resource/pubmed/id/16738692
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2006-7-20
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pubmed:abstractText |
Deletions of chromosome 6q have been reported in several hematological malignancies, but data are not conclusive regarding their biological and prognostic impact. Therefore, we focused on pediatric patients diagnosed with T-cell lymphoblastic lymphoma (T-LBL) treated uniformly according to the NHL-BFM95 protocol. We used loss-of-heterozygosity (LOH) analysis of 25 microsatellite markers located on chromosome 6q14-q24. Fragment-length analysis was performed on ABI-PRISM3100 Genetic-Analyzer. Eligibility criterion was > or =3 informative markers. Between April 1995 and March 2003, 185 T-LBL patients were treated according to the NHL-BFM95 protocol. Five-year event-free (EFS) and disease-free survival (DFS) were 79+/-3 and 87+/-3% (median follow-up 4.7 [1.2-10.1] years). Sixty-one patients were evaluable for LOH analysis, including 18 out of 23 patients with relapse. EFS and DFS were 67+/-6 and 69+/-6% for these 61 patients. Testing of 853 markers in the 61 patients identified the presence of LOH in 19 patients (31%): 13 of the 18 relapse patients and five of the 41 in complete remission (odds ratio 18.7, 95% confidence interval 4.7-75.3). One LOH-positive patient died from treatment-related toxicity. We conclude that LOH on chromosome 6q14-q24 may have conferred a high risk of relapse on our group of children with T-LBL treated according to the NHL-BFM95 protocol.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0887-6924
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1422-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16738692-Adolescent,
pubmed-meshheading:16738692-Child,
pubmed-meshheading:16738692-Chromosomes, Human, Pair 6,
pubmed-meshheading:16738692-Disease-Free Survival,
pubmed-meshheading:16738692-Female,
pubmed-meshheading:16738692-Humans,
pubmed-meshheading:16738692-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:16738692-Loss of Heterozygosity,
pubmed-meshheading:16738692-Male
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pubmed:year |
2006
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pubmed:articleTitle |
Loss of heterozygosity on chromosome 6q14-q24 is associated with poor outcome in children and adolescents with T-cell lymphoblastic lymphoma.
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pubmed:affiliation |
Department of Pediatric Hematology and Oncology, Justus-Liebig University, Giessen, Germany. birgit.brukhardt@paediat.med.uni-giessen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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