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rdf:type |
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lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0005149,
umls-concept:C0007584,
umls-concept:C0007613,
umls-concept:C0007806,
umls-concept:C0018894,
umls-concept:C0019704,
umls-concept:C0020852,
umls-concept:C0039194,
umls-concept:C0205307,
umls-concept:C0441889,
umls-concept:C0549193,
umls-concept:C1332714,
umls-concept:C1533691,
umls-concept:C1707455
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pubmed:issue |
5
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pubmed:dateCreated |
1991-5-28
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|
pubmed:abstractText |
Beta 2-microglobulin levels were measured in the cerebrospinal fluid (CSF) and serum of 163 human immunodeficiency virus-positive (HIV+) persons with normal neurologic physical examinations. None were on antiretroviral therapy. Only 3% had a positive CSF HIV p24 antigen test. The CSF beta 2-microglobulin levels increased as the CD4+ T cell count decreased. Intrathecal production of beta 2-microglobulin was suggested by finding CSF concentrations greater than serum concentrations in 15% of patients. The CSF beta 2-microglobulin levels rose as in vitro T helper cell function deteriorated, independent of CD4+ T cell count. CSF beta 2-microglobulin levels paralleled CSF IgG, IgG index, and IgG synthesis. Higher CSF beta 2-microglobulin levels were found in persons with positive CSF oligoclonal bands. CSF beta 2-microglobulin concentration may serve as a marker for subclinical neurologic damage due to HIV. If this is established, defining the effect of anti-HIV interventions on CSF beta 2-microglobulin would be warranted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1899
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
971-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1673466-Albumins,
pubmed-meshheading:1673466-Analysis of Variance,
pubmed-meshheading:1673466-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1673466-Female,
pubmed-meshheading:1673466-Gene Products, gag,
pubmed-meshheading:1673466-HIV Antigens,
pubmed-meshheading:1673466-HIV Core Protein p24,
pubmed-meshheading:1673466-HIV Infections,
pubmed-meshheading:1673466-HIV-1,
pubmed-meshheading:1673466-Humans,
pubmed-meshheading:1673466-Immunoglobulin G,
pubmed-meshheading:1673466-Leukocyte Count,
pubmed-meshheading:1673466-Male,
pubmed-meshheading:1673466-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:1673466-Viral Core Proteins,
pubmed-meshheading:1673466-beta 2-Microglobulin
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pubmed:year |
1991
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|
pubmed:articleTitle |
Comparison of spinal fluid beta 2-microglobulin levels with CD4+ T cell count, in vitro T helper cell function, and spinal fluid IgG parameters in 163 neurologically normal adults infected with the human immunodeficiency virus type 1.
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pubmed:affiliation |
Department of Medicine, Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas.
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pubmed:publicationType |
Journal Article
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