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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-5-29
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pubmed:abstractText |
Inadequate cyclosporine (CsA) blood levels are a major risk factor for acute rejection in transplant recipients. The CsA trough level (C0 level) measured just before the next dose is commonly used to adjust the oral dosage. However, the 2-hour post-CsA dose concentration (C2 level) is favored as the best single-point correlate of CsA area-under-the-curve concentration and may better reflect the immunosuppressive effect of CsA. Because an adequate C2 level has not yet been defined, this study was performed to assess the value of C2 monitoring for the prevention of acute rejection and to define target levels in pediatric heart transplant recipients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1557-3117
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pubmed:author |
pubmed-author:Abd El RahmanM YMY,
pubmed-author:Abdul-KhaliqHH,
pubmed-author:BergerFF,
pubmed-author:EwertPP,
pubmed-author:HüblerMM,
pubmed-author:HetzelHH,
pubmed-author:KrüdewagenBB,
pubmed-author:LehmkuhlH BHB,
pubmed-author:MieraOO,
pubmed-author:SchubertSS,
pubmed-author:WeiHH,
pubmed-author:WentJJ
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
619-25
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pubmed:meshHeading |
pubmed-meshheading:16730566-Adolescent,
pubmed-meshheading:16730566-Antilymphocyte Serum,
pubmed-meshheading:16730566-Area Under Curve,
pubmed-meshheading:16730566-Child,
pubmed-meshheading:16730566-Cyclosporine,
pubmed-meshheading:16730566-Female,
pubmed-meshheading:16730566-Graft Rejection,
pubmed-meshheading:16730566-Heart Transplantation,
pubmed-meshheading:16730566-Humans,
pubmed-meshheading:16730566-Immunosuppressive Agents,
pubmed-meshheading:16730566-Male,
pubmed-meshheading:16730566-Methylprednisolone,
pubmed-meshheading:16730566-Monitoring, Physiologic,
pubmed-meshheading:16730566-Pulse Therapy, Drug,
pubmed-meshheading:16730566-Sensitivity and Specificity,
pubmed-meshheading:16730566-T-Lymphocytes
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pubmed:year |
2006
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pubmed:articleTitle |
Advantages of C2 monitoring to avoid acute rejection in pediatric heart transplant recipients.
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pubmed:affiliation |
Department of Congenital Heart Defects/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany. sschubert@dhzb.de
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pubmed:publicationType |
Journal Article
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