Linked Life Data

1672899

Source:http://linkedlifedata.com/resource/pubmed/id/1672899

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-5-16
pubmed:abstractText
GABAergic involvement in the regulation of intestinal ion transport is suggested by the reduction in the short-circuit current generated by sheets of rat small intestine by the GABA antagonist bicuculline, although GABA itself caused no change. Bicuculline action was abolished by the inhibitor of Cl- secretion frusemide, suggesting that it involved a change in endogenous Cl- secretory tone. The effect of bicuculline appeared to be specific as it did not affect the electrical responses to glucose or exogenous secretagogues. The action of bicuculline was not observed in stripped intestinal sheets where the myenteric plexus is absent, and it was reduced by tetrodotoxin and atropine. It is suggested that endogenous GABA could be involved in the maintenance of a secretory tone in rat small intestine by acting on cholinergic mechanisms within the myenteric plexus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3573
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
128-30
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The influence of the gamma-amino butyric acid (GABA) antagonist bicuculline on transport processes in rat small intestine.
pubmed:affiliation
Department of Biomedical Science, The University, Sheffield, UK.
pubmed:publicationType
Journal Article