Linked Life Data

1672898

Source:http://linkedlifedata.com/resource/pubmed/id/1672898

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-5-16
pubmed:abstractText
An electrochemical approach to the determination of permeability through native mucus gel of simple electrochemically active solutes is reported. For all the solutes studied, a reduction in effective diffusion coefficients was observed, with retardation of solute flux by a factor of at least two. However, NADH and the dicarboxylic acid derivative of ferrocene demonstrated a substantial, almost ten-fold, reduction in permeability through mucus. Results for the controls were in reasonable agreement with literature values where available. No consistent effect of molecular weight was evident with regard to the barrier properties of mucus over the molecular weight range of solutes investigated (34-660 daltons). The results suggest that mucus is acting more than as a gel support for an unstirred water layer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3573
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
124-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Electrochemical determination of the permeability of porcine mucus to model solute compounds.
pubmed:affiliation
Department of Medicine, University of Manchester, Hope Hospital, Salford, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't