Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-5-26
pubmed:abstractText
Monoclonal antibodies to human estrogen receptor were used with an indirect immunohistochemical technique to localize in formalin-fixed, paraffin-embedded sections of the genital tract of the bitch. The presence of estrogen receptors in the uterus of dogs with cystic hyperplasia endometritis complex (CHE) was compared with normal uteri from dogs at the same stage of estrous cycle. Lower estrogen receptor expression was found in the squamous metaplastic epithelium covering the luminal surface of the endometrium from dogs with CHE than in the columnar epithelium from normal dogs. In contrast, the basal glands from uteri of CHE group dogs contained more estrogen receptor than glands from normal dogs at the same stage of estrous cycle. This was most pronounced and statistically significant in the late secretary stage of the estrous cycle. When the glands presented cystic degeneration, the estrogen receptor labeling was less pronounced. The highest estrogen receptor score was present in normal glands from dogs treated with progestins. In this group even cystic degenerated glands contained high estrogen receptor concentrations compared with those of the other groups. From this study it was concluded that the down regulation of estrogen receptor expression in the endometrial glands under the influence of rising progesterone concentrations is defective in dogs with CHE. Therefore it is suggested that the regulation of estrogen receptor expression in endometrial glands may play an important role in the pathogenesis of CHE in the bitch.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Oct
pubmed:issn
0093-691X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1035-47
pubmed:year
1997
pubmed:articleTitle
Immunohistochemical analysis of estrogen receptors in cystic-endometritis-pyometra complex in the bitch.
pubmed:affiliation
Laboratory of Veterinary Pathology Faculty of Veterinary Medicine RUG, Casinoplein 24, 9000 Gent, Belgium.
pubmed:publicationType
Journal Article