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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-4-25
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pubmed:abstractText |
Single oral administration of modafinil (16-64 mg/kg) in monkeys induced an increase in nocturnal activity and in behavioural arousal without stereotyped behaviour. Modafinil-induced increase in nocturnal activity was prevented by the centrally acting alpha 1 adrenoceptor antagonist prazosin. After repeated oral administration of modafinil, b.i.d. for 5 days, nocturnal activity was still increased, but was lower than after a single administration; the gradual decrease appeared on the second night. No rebound of sleep and no residual effect on night 5 (when modafinil was administered for 4 days and placebo on day 5) were seen after the withdrawal of the drug. Therefore, modafinil appeared to produce strong behavioural stimulation and awakening in a non-human primate species, after single, as well as after repeated administration, without other obvious side-effects (no sign of anxiety, no behavioural trouble). These awakening properties involved a modulation (stimulation) of a central alpha 1 adrenergic system.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0033-3158
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28-32
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1672457-Administration, Oral,
pubmed-meshheading:1672457-Animals,
pubmed-meshheading:1672457-Arousal,
pubmed-meshheading:1672457-Benzhydryl Compounds,
pubmed-meshheading:1672457-Central Nervous System Stimulants,
pubmed-meshheading:1672457-Macaca mulatta,
pubmed-meshheading:1672457-Male,
pubmed-meshheading:1672457-Motor Activity,
pubmed-meshheading:1672457-Prazosin,
pubmed-meshheading:1672457-Wakefulness
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pubmed:year |
1991
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pubmed:articleTitle |
Awakening properties of modafinil: effect on nocturnal activity in monkeys (Macaca mulatta) after acute and repeated administration.
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pubmed:affiliation |
Centre de Recherches du Laboratoire L. Lafon, Maisons-Alfort, France.
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pubmed:publicationType |
Journal Article
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