|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2006-7-10
|
|
pubmed:abstractText |
IL-1beta released from immune cells induces beta cell pro-apoptotic signalling via mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB). In neurons, the neural cell adhesion molecule (NCAM) signals to several elements involved in IL-1beta-induced pro-apoptotic signalling in beta cells. Pancreatic beta cells express NCAM, but its biological effects in these cells are unclear. The aim of this study was to investigate whether there is cross-talk between NCAM signalling and cytokine-induced pro-apoptotic signalling.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0012-186X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1864-75
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16718462-Animals,
pubmed-meshheading:16718462-Cell Line,
pubmed-meshheading:16718462-Complement C3d,
pubmed-meshheading:16718462-Hippocampus,
pubmed-meshheading:16718462-Insulin-Secreting Cells,
pubmed-meshheading:16718462-Insulinoma,
pubmed-meshheading:16718462-Interleukin-1,
pubmed-meshheading:16718462-Neural Cell Adhesion Molecules,
pubmed-meshheading:16718462-Neurons,
pubmed-meshheading:16718462-Pancreatic Neoplasms,
pubmed-meshheading:16718462-Phosphorylation,
pubmed-meshheading:16718462-Pyrroles,
pubmed-meshheading:16718462-Rats,
pubmed-meshheading:16718462-Rats, Wistar,
pubmed-meshheading:16718462-Receptor, Fibroblast Growth Factor, Type 1,
pubmed-meshheading:16718462-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:16718462-Recombinant Proteins,
pubmed-meshheading:16718462-Signal Transduction,
pubmed-meshheading:16718462-Tumor Cells, Cultured
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line.
|
|
pubmed:affiliation |
Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
