rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2006-7-3
|
pubmed:abstractText |
This study examined regional changes in rat brain mRNA levels encoding 5-HT(2A) and 5-HT(2C) receptors following chronic olanzapine treatment. The immediate effect (2h after the last treatment) was a down-regulation of 5-HT(2A) receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT(2C) receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT(2A) receptor mRNA expression and total food intake, weight gain and energy efficiency were observed.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzodiazepines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2C,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/olanzapine
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0166-4328
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
10
|
pubmed:volume |
171
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
355-62
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:16716417-Analysis of Variance,
pubmed-meshheading:16716417-Animals,
pubmed-meshheading:16716417-Benzodiazepines,
pubmed-meshheading:16716417-Brain,
pubmed-meshheading:16716417-Down-Regulation,
pubmed-meshheading:16716417-Female,
pubmed-meshheading:16716417-Gene Expression Regulation,
pubmed-meshheading:16716417-RNA, Messenger,
pubmed-meshheading:16716417-Random Allocation,
pubmed-meshheading:16716417-Rats,
pubmed-meshheading:16716417-Rats, Sprague-Dawley,
pubmed-meshheading:16716417-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:16716417-Receptor, Serotonin, 5-HT2C,
pubmed-meshheading:16716417-Serotonin Uptake Inhibitors
|
pubmed:year |
2006
|
pubmed:articleTitle |
Olanzapine differentially affects 5-HT2Aand2C receptor mRNA expression in the rat brain.
|
pubmed:affiliation |
Neurobiology Research Centre of Metabolic and Psychiatric Disorders, School of Health Science, University of Wollongong, NSW, Australia.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|