Linked Life Data

16713113

Source:http://linkedlifedata.com/resource/pubmed/id/16713113

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-7-24
pubmed:abstractText
There are increasing data in support of the hypothesis that inflammatory cytokines are involved in neonatal white matter damage. Despite extensive study of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta, the role of interleukin-6 in the development of white matter damage is largely unknown. In the present study, the role(s) of interleukin-6 in mediating lipopolysaccharide-induced brain injury and behavioral changes was investigated by the intracerebral injection of lipopolysaccharide with interleukin-6 neutralizing antibody in the 5-day-old rat brain. Brain injury was examined in brain sections at postnatal day 8 and postnatal day 21. Behavioral tests including righting reflex, wire hanging maneuver, cliff avoidance, locomotor activity, gait analysis, responses in the elevated plus-maze and passive avoidance were performed from postnatal day 3 to postnatal day 21. Changes in astroglia, microglia and oligodendrocytes were studied using immunohistochemistry in the postnatal day 21 rat brain. Our results show that interleukin-6 antibody attenuated lipopolysaccharide-induced brain lateral ventricle dilation and improved neurobehavioral performance. Interleukin-6 antibody also suppressed lipopolysaccharide-induced astrogliosis and microglial activation, and increased the number of oligodendrocytes in white matter. However, no changes of tumor necrosis factor-alpha and interleukin-1beta were detected. In contrast, no histopathological changes and glial activation were observed in rats injected with only interleukin-6. The present study indicates that the contribution to brain injury by interleukin-6 depends on its interaction with other lipopolysaccharide-induced agents and not on interleukin-6 alone.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
745-55
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:16713113-Age Factors, pubmed-meshheading:16713113-Animals, pubmed-meshheading:16713113-Animals, Newborn, pubmed-meshheading:16713113-Antibodies, pubmed-meshheading:16713113-Avoidance Learning, pubmed-meshheading:16713113-Behavior, Animal, pubmed-meshheading:16713113-Body Weight, pubmed-meshheading:16713113-Brain Injuries, pubmed-meshheading:16713113-Cell Count, pubmed-meshheading:16713113-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:16713113-Female, pubmed-meshheading:16713113-Immunohistochemistry, pubmed-meshheading:16713113-Interleukin-1, pubmed-meshheading:16713113-Interleukin-6, pubmed-meshheading:16713113-Lipopolysaccharides, pubmed-meshheading:16713113-Male, pubmed-meshheading:16713113-Maze Learning, pubmed-meshheading:16713113-Motor Activity, pubmed-meshheading:16713113-Psychomotor Performance, pubmed-meshheading:16713113-Rats, pubmed-meshheading:16713113-Rats, Sprague-Dawley, pubmed-meshheading:16713113-Tumor Necrosis Factor-alpha
pubmed:year
2006
pubmed:articleTitle
Role of interleukin-6 in lipopolysaccharide-induced brain injury and behavioral dysfunction in neonatal rats.
pubmed:affiliation
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural