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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-6-16
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pubmed:abstractText |
The transcription factor LBP-1c/CP2/LSF (LBP-1c) is a candidate gene for Alzheimer's disease (AD) because it is located in a putative hotspot for an AD risk gene on chromosome 12. We investigated the effect of LBP-1c polymorphism on the risk of AD in 162 AD patients, 180 patients with major depression as hospitalized controls and 225 healthy subjects. We observed no significant association of the LBP-1c A allele with AD. Nor did we detect an interaction of the LBP-1c A allele with the apolipoprotein E4 (ApoE4) allele or the low-density lipoprotein receptor-related protein T allele which could have been related to the risk of AD. However, exploratory data analysis revealed that the LBP-1c A allele might act as a protective factor in major depression. A recent study also described an association of another gene located on chromosome 12, the mannose 6-phosphatase receptor gene, with major depression. These data suggest the presence of a putative risk gene for major depression at chromosome 12.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein E4,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/TFCP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:issn |
1420-8008
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-8
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pubmed:dateRevised |
2008-3-24
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pubmed:meshHeading |
pubmed-meshheading:16710089-Aged,
pubmed-meshheading:16710089-Alleles,
pubmed-meshheading:16710089-Alzheimer Disease,
pubmed-meshheading:16710089-Apolipoprotein E4,
pubmed-meshheading:16710089-Apolipoproteins E,
pubmed-meshheading:16710089-Chromosomes, Human, Pair 12,
pubmed-meshheading:16710089-DNA,
pubmed-meshheading:16710089-DNA-Binding Proteins,
pubmed-meshheading:16710089-Depressive Disorder, Major,
pubmed-meshheading:16710089-Female,
pubmed-meshheading:16710089-Gene Frequency,
pubmed-meshheading:16710089-Humans,
pubmed-meshheading:16710089-Logistic Models,
pubmed-meshheading:16710089-Male,
pubmed-meshheading:16710089-Polymorphism, Genetic,
pubmed-meshheading:16710089-Receptor, IGF Type 2,
pubmed-meshheading:16710089-Receptors, LDL,
pubmed-meshheading:16710089-Risk,
pubmed-meshheading:16710089-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Association of polymorphism in the transcription factor LBP-1c/CP2/LSF gene with Alzheimer's disease and major depression.
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pubmed:affiliation |
Department of Psychiatry, University of Bonn, Bonn, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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